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RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis."

1 Jun 2023

St. Jude discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme.

1 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

Peptidomimetic antibiotics may be effective against resistant bacteria

Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers at the University of Zurich and the company Spexis have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to novel targets in the bacteria's metabolism.

1 Jun 2023

Key insights into immune responses after COVID-19 vaccination in Indigenous people

Researchers evaluated immune responses to COVID-19 BNT162b2 mRNA vaccinations among Indigenous Australian First Nations (FN) individuals by comorbidity and ethnicity.

1 Jun 2023

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

1 Jun 2023

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

Scientists at Tohoku University have discovered a novel approach that improves the efficacy of immune checkpoint blockade (ICB) - a novel form of cancer treatment utilizing immune checkpoint inhibitors (ICIs) - and minimizes the associated side effects.

1 Jun 2023

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) occurs in 30% of hospitalized cirrhosis patients, leading to over one million deaths worldwide each year.

31 May 2023

Spice up your heart health: Taurine and black pepper combo shows promising cardioprotective effects

Taurine and black pepper, along with key terpene constituents, are investigated for their potential in reducing cardiovascular risk factors and combating related diseases in this comprehensive literature review. Their cardioprotective effects and mechanisms are explored.

31 May 2023

Study unlocks insights into how 'good fat' tissue could be harnessed to combat obesity, diabetes

New research has unlocked insights into how "good fat" tissue could potentially be harnessed to combat obesity and remove glucose from the blood, helping to control diabetes.

31 May 2023

First-in-human clinical trial of liver dialysis device successfully completed

The first successful in-patient trial of liver dialysis* has been completed by researchers from UCL, the Royal Free Hospital, UCL spin-out Yaqrit and their collaborators.

31 May 2023

Breast cancer patients experience more severe CIPN symptoms with paclitaxel

Chemotherapy-induced peripheral neuropathy (CIPN) – nerve pain, tingling, or numbness in the hands or feet – is a common side effect of certain cancer treatments, including two drugs frequently used to treat cancer – the taxanes paclitaxel and docetaxel.

31 May 2023

Groundbreaking 3D imaging unveils secrets of cilia

Study provides a comprehensive analysis of human primary cilia, uncovering their architectural features and functional implications in cellular processes. It highlights the importance of these sensory organelles in signaling, motility, and intercellular communication.

31 May 2023

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

Acting as a team, twin stem cells activate the immune system to suppress tumor growth and prolong survival in representative preclinical models.

31 May 2023

New insights into how axons grow could lead to effective therapies for blindness, paralysis

Injuries to the nerves can blind or paralyze because adult nerve cells don't regenerate their connections. Now, a team of UConn School of Medicine researchers report in Development that at least a small population of nerve cells exist in everyone that could be coaxed to regrow, potentially restoring sight and movement.

31 May 2023

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Researchers from Children's Hospital of Philadelphia, the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the Children's Brain Tumor Network, the Pacific Pediatric Neuro-Oncology Consortium, and more than 20 additional institutions have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors.

31 May 2023

Autoantibodies against 'synaptic adhesion protein' can cause schizophrenia-related changes

Links have been reported between schizophrenia and proteins produced by the immune system that can act against one's own body, known as autoantibodies.

31 May 2023

New insight into how click chemistry EV/peptide/chemokine nanomissiles repair CNS injuries

This new article publication from Acta Pharmaceutica Sinica B, discusses click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries.

31 May 2023

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Cell News and Research

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

St. Jude discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Peptidomimetic antibiotics may be effective against resistant bacteria

Key insights into immune responses after COVID-19 vaccination in Indigenous people

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

Novel approach improves the efficacy of immune checkpoint blockade and minimizes related side effects

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Spice up your heart health: Taurine and black pepper combo shows promising cardioprotective effects

Study unlocks insights into how 'good fat' tissue could be harnessed to combat obesity, diabetes

First-in-human clinical trial of liver dialysis device successfully completed

Breast cancer patients experience more severe CIPN symptoms with paclitaxel

Groundbreaking 3D imaging unveils secrets of cilia

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

New insights into how axons grow could lead to effective therapies for blindness, paralysis

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Autoantibodies against 'synaptic adhesion protein' can cause schizophrenia-related changes

New insight into how click chemistry EV/peptide/chemokine nanomissiles repair CNS injuries

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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