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St. Jude discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme.

1 Jun 2023

Severe COVID-19 raises alarm for undiagnosed cancer

Severe SARS-CoV-2 infection is associated with a 1.31 higher risk of being diagnosed with cancer following hospital discharge, particularly renal, hematological, colon, and lung cancers, suggesting a potential link between the infection and undiagnosed cancer.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

Miniature video capsule shows capabilities like a traditional tube-based endoscopy

While ingestible video capsule endoscopes have been around for many years, the capsules have been limited by the fact that they could not be controlled by physicians.

1 Jun 2023

Accounting for genetic factors can improve accuracy of prostate cancer screening

The accuracy of prostate-specific antigen (PSA) screening for prostate cancer can be improved by accounting for genetic factors that cause changes in PSA levels that are not associated with cancer, according to a multi-center study led by UC San Francisco and Stanford University.

1 Jun 2023

The association between COVID-19 vaccination types and doses with adverse outcomes of SARS-CoV-2

Researchers investigated the associations between coronavirus disease 2019 vaccination or non-vaccination and adverse outcomes.

1 Jun 2023

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Over 2,800 cases, representing a 31% increase, added to BGI Genomics-led CardioGen's hereditary cardiovascular disease gene data.

From BGI Genomics 1 Jun 2023

Special issue aims to deepen the conversation around cerebral palsy

Although cerebral palsy (CP) is the most common childhood-onset disability, there are very few evidence-based clinical practice guidelines or recommendations on how to treat and manage this condition.

31 May 2023

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) occurs in 30% of hospitalized cirrhosis patients, leading to over one million deaths worldwide each year.

31 May 2023

First-in-human clinical trial of liver dialysis device successfully completed

The first successful in-patient trial of liver dialysis* has been completed by researchers from UCL, the Royal Free Hospital, UCL spin-out Yaqrit and their collaborators.

31 May 2023

New variants of human metapneumovirus surge in Spain post-COVID, highlighting evolution and impact

Investigating Human metapneumovirus (HMPV) prevalence, genetic diversity, and evolution in respiratory tract infections (RTIs) for better understanding and management.

31 May 2023

Spike in childhood human metapneumovirus infections in Western Australia linked to reduced COVID-19 measures

Researchers investigated the prevalence of human metapneumovirus through 2020 considering the implementation of NPIs due to the COVID-19 pandemic.

31 May 2023

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

Acting as a team, twin stem cells activate the immune system to suppress tumor growth and prolong survival in representative preclinical models.

31 May 2023

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Researchers from Children's Hospital of Philadelphia, the Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, the Children's Brain Tumor Network, the Pacific Pediatric Neuro-Oncology Consortium, and more than 20 additional institutions have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors.

31 May 2023

Long-term consequences of COVID-19 in patients with inflammatory rheumatic diseases

Studies on the long-term consequences of COVID-19 (long-COVID) in patients with inflammatory rheumatic diseases (iRD) are scarce.

31 May 2023

Health care coalition jockeys over Medi-Cal spending, eyes ballot initiative

Influential health care interests are jockeying over a potential infusion of $19.4 billion into Medi-Cal, California's Medicaid program, while also angling for a 2024 ballot initiative to permanently lock in that funding, KFF Health News has learned.

31 May 2023

How a medical recoding may limit cancer patients’ options for breast reconstruction

The federal government is reconsidering a decision that breast cancer patients, plastic surgeons, and members of Congress have protested would limit women's options for reconstructive surgery.

31 May 2023

Aggressive lung pathogen may not be prone to person-to-person transmission

A little-known bacterium -; a distant cousin of the microbes that cause tuberculosis and leprosy -; is emerging as a public health threat capable of causing severe lung infections among vulnerable populations, those with compromised immunity or reduced lung function.

30 May 2023

Extended lymphadenectomy for locally advanced bladder cancer provides no patient benefit

An extended lymphadenectomy – removal of additional lymph nodes beyond the extent of the standard procedure – in patients undergoing radical cystectomy (removal of bladder and nearby tissues) because of clinically localized muscle-invasive bladder cancer provides no patient benefit as measured by disease-free survival or overall survival times.

30 May 2023

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Hospital News and Research

St. Jude discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Severe COVID-19 raises alarm for undiagnosed cancer

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Miniature video capsule shows capabilities like a traditional tube-based endoscopy

Accounting for genetic factors can improve accuracy of prostate cancer screening

The association between COVID-19 vaccination types and doses with adverse outcomes of SARS-CoV-2

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Special issue aims to deepen the conversation around cerebral palsy

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

First-in-human clinical trial of liver dialysis device successfully completed

New variants of human metapneumovirus surge in Spain post-COVID, highlighting evolution and impact

Spike in childhood human metapneumovirus infections in Western Australia linked to reduced COVID-19 measures

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

Researchers create an open-source, reproducible analysis platform for pediatric brain tumors

Long-term consequences of COVID-19 in patients with inflammatory rheumatic diseases

Health care coalition jockeys over Medi-Cal spending, eyes ballot initiative

How a medical recoding may limit cancer patients’ options for breast reconstruction

Aggressive lung pathogen may not be prone to person-to-person transmission

Extended lymphadenectomy for locally advanced bladder cancer provides no patient benefit

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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