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MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

Researchers evaluated the potential of three licorice (Glycyrrhiza) species, i.e., G. glabra (GG), G. uralensis (GU), and G. infata (GI), and hops (Humulus lupulus), and their main bioactive polyphenols, to prevent breast malignancy.

1 Jun 2023

Chemical found in widely used sweetener breaks up DNA

A new study finds a chemical formed when we digest a widely used sweetener is "genotoxic," meaning it breaks up DNA.

31 May 2023

New insight into how click chemistry EV/peptide/chemokine nanomissiles repair CNS injuries

This new article publication from Acta Pharmaceutica Sinica B, discusses click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries.

31 May 2023

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Scientists have identified a lipid-degrading enzyme as a prognostic biomarker for luminal breast cancer.

31 May 2023

Dutch scientists unveil the integral role of CD5L protein in IgM structure and function

Researchers in the Netherlands assessed the structure of human circulatory IgM and its relationship with the small CD5L protein.

31 May 2023

Study shows impacts of ASO-based MALAT1-inhibition on MAPK-pathway gene regulation in melanoma

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment."

30 May 2023

Novel technology enhances potency and breadth of vaccine-induced responses through antigen presentation

Novel EABR technology enhances potency and breadth of vaccine-induced responses through antigen presentation.

30 May 2023

Energy drinks may stunt muscle repair, new study suggests

Energy drinks impede muscle regeneration and reduce physical performance. This study provided evidence of an inhibitory effect on myogenic differentiation and highlighted potential concerns for athletes and fitness enthusiasts.

29 May 2023

Novel assay for identifying individuals with synucleinopathies using serum samples

Synucleinopathies are a group of neurodegenerative diseases caused by the abnormal accumulation α-synuclein, a protein normally found in the brain and neurons. Incorrect folding of α-synuclein leads to formation of 'seeds', which attract more α-synuclein proteins to form larger clumps.

29 May 2023

World’s first childbirth following a uterus transplantation achieved solely by robot-assisted surgery

For the first time worldwide, in yet another breakthrough by the world-leading research team at the University of Gothenburg, a child has been born following a uterus transplantation achieved solely by robot-assisted surgery on both donor and recipient.

26 May 2023

The potential clinical benefit of the Multabody platform as a therapeutic for SARS-CoV-2

The potential clinical benefit of the Multabody platform as a therapeutic for SARS-CoV-2.

26 May 2023

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

Researchers develop a lipid nanoparticle-formulated mRNA-based antigen encoding three SARS-CoV-2 peptides derived from non-structural proteins.

25 May 2023

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

A new research paper was published in Oncotarget's Volume 14 on May 19, 2023, entitled, "G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis."

23 May 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

Newly discovered molecule effectively destroys senescent cells

Over time, the body's cells stop working properly and begin to accumulate, which eventually leads to tissues aging.

22 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

Researchers find that SARS-CoV-2 directly infects hepatocytes that cause hyperglycemia

Researchers investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused hyperglycemia.

18 May 2023

in vitro News and Research

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Study suggests licorice-derived liquiritigenin has breast cancer prevention potential for high-risk postmenopausal women

Chemical found in widely used sweetener breaks up DNA

New insight into how click chemistry EV/peptide/chemokine nanomissiles repair CNS injuries

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Dutch scientists unveil the integral role of CD5L protein in IgM structure and function

Study shows impacts of ASO-based MALAT1-inhibition on MAPK-pathway gene regulation in melanoma

Novel technology enhances potency and breadth of vaccine-induced responses through antigen presentation

Energy drinks may stunt muscle repair, new study suggests

Novel assay for identifying individuals with synucleinopathies using serum samples

World’s first childbirth following a uterus transplantation achieved solely by robot-assisted surgery

The potential clinical benefit of the Multabody platform as a therapeutic for SARS-CoV-2

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Newly discovered molecule effectively destroys senescent cells

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers find that SARS-CoV-2 directly infects hepatocytes that cause hyperglycemia

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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