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New genetic risk factors for Alzheimer’s disease unique to Ashkenazi Jews identified

Alzheimer disease (AD), the most common neurodegenerative disorder in the world, affects individuals of all races and ethnicities; however, most genetic research for AD has been performed on individuals of European ancestry (EA) with a limited number of large-scale genetic studies in other populations.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

New data guides treatment choices for patients with r/r lymphoma during pregnancy

Today, Blood Advances published a study revealing that patients with relapsed/refractory (r/r) lymphoma during pregnancy experienced a progression-free survival rate of 24% and an overall survival rate of 83%.

1 Jun 2023

Miniature video capsule shows capabilities like a traditional tube-based endoscopy

While ingestible video capsule endoscopes have been around for many years, the capsules have been limited by the fact that they could not be controlled by physicians.

1 Jun 2023

Accounting for genetic factors can improve accuracy of prostate cancer screening

The accuracy of prostate-specific antigen (PSA) screening for prostate cancer can be improved by accounting for genetic factors that cause changes in PSA levels that are not associated with cancer, according to a multi-center study led by UC San Francisco and Stanford University.

1 Jun 2023

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

1 Jun 2023

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Over 2,800 cases, representing a 31% increase, added to BGI Genomics-led CardioGen's hereditary cardiovascular disease gene data.

From BGI Genomics 1 Jun 2023

Pilot study reveals effective approach to boost adherence to Mediterranean ketogenic diet for memory concerns in older adults

Researchers explored strategies for enhancing compliance with a Mediterranean ketogenic nutrition program among older individuals.

1 Jun 2023

Special issue aims to deepen the conversation around cerebral palsy

Although cerebral palsy (CP) is the most common childhood-onset disability, there are very few evidence-based clinical practice guidelines or recommendations on how to treat and manage this condition.

31 May 2023

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) occurs in 30% of hospitalized cirrhosis patients, leading to over one million deaths worldwide each year.

31 May 2023

Novel phototherapy device could have potential therapeutic benefits for sleep and daytime functioning

Wearing a phototherapy device that emits near-infrared light is associated with potential therapeutic benefits for sleep and daytime functioning, according to a new study to be presented at the SLEEP 2023 annual meeting.

31 May 2023

Study unlocks insights into how 'good fat' tissue could be harnessed to combat obesity, diabetes

New research has unlocked insights into how "good fat" tissue could potentially be harnessed to combat obesity and remove glucose from the blood, helping to control diabetes.

31 May 2023

Protein discovery could open up new treatment options for chronic kidney disease

Fresh insights into a protein that causes damage in kidneys and hearts could open up new treatment options for chronic kidney disease, research shows.

31 May 2023

NIH scientists identify genomic variants that cause rare inflammatory skin disorder

Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.

31 May 2023

First-in-human clinical trial of liver dialysis device successfully completed

The first successful in-patient trial of liver dialysis* has been completed by researchers from UCL, the Royal Free Hospital, UCL spin-out Yaqrit and their collaborators.

31 May 2023

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

Acting as a team, twin stem cells activate the immune system to suppress tumor growth and prolong survival in representative preclinical models.

31 May 2023

New insights into how axons grow could lead to effective therapies for blindness, paralysis

Injuries to the nerves can blind or paralyze because adult nerve cells don't regenerate their connections. Now, a team of UConn School of Medicine researchers report in Development that at least a small population of nerve cells exist in everyone that could be coaxed to regrow, potentially restoring sight and movement.

31 May 2023

Babies experiencing hypoxia due to sleep apnea tend to develop hypertension in adulthood

Newborn babies who experience low levels of oxygen in their body tissues (hypoxia) due to sleep apnea, for example, tend to develop respiratory problems and hypertension (high blood pressure) in adulthood, and these problems may persist for the rest of their lives.

31 May 2023

Most American Indian/Alaska Native women of childbearing age have suboptimal heart health, AHA reports

Heart health risks emerge early in life in American Indian/Alaska Native (AI/AN) women and are increased by social factors -; like high levels of experiencing violence and traumatic life events -; and disproportionately high rates of Type 2 diabetes, smoking and obesity, according to a new scientific statement published today in Circulation: Cardiovascular Quality and Outcomes, a peer-reviewed American Heart Association journal.

31 May 2023

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Medicine News and Research

New genetic risk factors for Alzheimer’s disease unique to Ashkenazi Jews identified

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

New data guides treatment choices for patients with r/r lymphoma during pregnancy

Miniature video capsule shows capabilities like a traditional tube-based endoscopy

Accounting for genetic factors can improve accuracy of prostate cancer screening

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

CardioGen upgrade facilitates more accurate diagnosis of monogenic cardiovascular diseases

Pilot study reveals effective approach to boost adherence to Mediterranean ketogenic diet for memory concerns in older adults

Special issue aims to deepen the conversation around cerebral palsy

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Novel phototherapy device could have potential therapeutic benefits for sleep and daytime functioning

Study unlocks insights into how 'good fat' tissue could be harnessed to combat obesity, diabetes

Protein discovery could open up new treatment options for chronic kidney disease

NIH scientists identify genomic variants that cause rare inflammatory skin disorder

First-in-human clinical trial of liver dialysis device successfully completed

Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas

New insights into how axons grow could lead to effective therapies for blindness, paralysis

Babies experiencing hypoxia due to sleep apnea tend to develop hypertension in adulthood

Most American Indian/Alaska Native women of childbearing age have suboptimal heart health, AHA reports

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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