Cell Biology - Peak proteomics productivity for degenerative neurological disease research
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  Cell Biology  
  The latest cell & molecular biology news from News Medical  
 

Free Poster: Novel Bioassays in PicodropletsFree Poster: Novel Bioassays in Picodroplets

Using microfluidic devices with well-defined microchannel geometries and accurate flow control, uniform picolitre volume droplets (picodroplets) can be generated and used as miniaturized “test tubes” for high-throughput bioassays. Confining individual cells into picodroplets enables the implementation of a range of novel bioassays and applications in biotherapeutic discovery and development, cell therapy research, genome editing, and immuno-oncology.

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    Peak proteomics productivity for degenerative neurological disease researchPeak proteomics productivity for degenerative neurological disease research
 
The Roberts Lab at Emory University School of Medicine in Atlanta is focussed on the study of proteins and metalloproteins as biomarkers for neurological disorders. The lab initially purchased a single VOYAGER adjustable tip spacing pipette to increase the efficiency and accuracy of its proteomics workflow, but was so impressed with the increased throughput that it is now employing several of these versatile multichannel pipettes for a wide range of laboratory tasks.
 
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   Cytoelectric Coupling hypothesis: Fluctuating electric fields shape the brain’s molecular infrastructureCytoelectric Coupling hypothesis: Fluctuating electric fields shape the brain’s molecular infrastructure
 
To produce its many functions, including thought, the brain works at many scales. Information such as goals or images is represented by coordinated electrical activity among networks of neurons, while within and around each neuron a mix of proteins and other chemicals physically carries out the mechanics of participating in the network.
 
 Investigating the interplay between white blood cell count and incidence of hyper-low-density lipoprotein cholesterolemia
 
Investigating the interplay between white blood cell count and incidence of hyper-low-density lipoprotein cholesterolemiaResearchers investigating the association between white blood cell count and LDL hypercholesteremia.
 
 
 COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm
 
COVID-19 'bites the apple': Abdominal obesity ignites cytokine stormAbdominal obesity increases the risk of severe COVID-19 and mortality due to heightened inflammatory responses, according to a study on Japanese patients and a murine COVID-19 model. Blocking inflammatory cytokines and preventing obesity may improve survival rates.
 
 
 Treatment with luspatercept improves red blood cell counts in patients with myelodysplastic syndromes
 
Treatment with luspatercept improves red blood cell counts in patients with myelodysplastic syndromesTreatment with luspatercept improved red blood cell counts and erythroid responses compared to treatment with epoetin alfa in patients with myelodysplastic syndromes (MDS), allowing the majority to no longer require regular blood transfusions.
 
 
 Role of SWI/SNF Chromatin Remodeling Complex in Cell Division
 
Role of SWI/SNF Chromatin Remodeling Complex in Cell DivisionA previously unknown function for the SWI/SNF chromatin remodeling complex has been revealed by researchers at St. Jude Children’s Research Hospital.
 
 
 How the Disturbed Recycling Chain of Endoplasmic Reticulum Causes Neurodegenerative Diseases
 
How the Disturbed Recycling Chain of Endoplasmic Reticulum Causes Neurodegenerative DiseasesOur cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.
 
 

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